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Just reading an article talking about the LT1 engine from MotorTrend: "Speaking of cams, the LT1’s is said to be based on the LS3 and specs out at 200/207 duration at 0.050 and 0.551/0.524-inch lift on a 116.5 LSA, with lift events having been optimized based on the new higher rocker ratio and splayed valve geometry. The cam opening and closing ramps were tailored to accommodate AFM, and as with prior AFM-equipped engines, the cam lobe profiles are slightly different on cylinders that have the deactivating lifters (i.e., cylinders 1, 7, 6, and 4). According to John Rydzewski, “This is always the case with AFM because you have to accommodate some additional lash with the AFM hardware. In addition to that, on both the deactivating and non-deactivating cylinders, we did some work on opening and closing ramps for noise refinement.” He emphasized the slight difference in the cam lobes does not affect airflow cylinder to cylinder."
LT4 cam with DOD should be similar.
I would think that you could run a DOD cam with non-DOD lifters and it would be fine. You would likely need to use different length pushrods for those cylinders. But you would be putting different stresses/forces on those different cylinders which is probably not good.
Definitely better to go with a non-DOD cam. And I am sure if you wanted to stay at stock lift and duration, CamMotion or Comp could make that for you.
As for plugging the oil passages for the DOD, I would do it as it could be a way to loose a lot of oil pressure.
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