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If you remove the tire and flip the tire around you will need to rebalance the tire/wheel assembly. The tire has a three dimensional balance and is not totally uniform (i.e. different side wall flex from side to side around the tire, etc). The same 3 D balance issue is true of the wheel (usually to a lesser extent though). OEMs usually match balance and road force balance a tire/wheel assembly. Flipping the tire around may cause a small vibration or a very harsh one so I would rebalance and do a road force measurement on the assembly.
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